Publications
Bibliography in NCBI: https://www.ncbi.nlm.nih.gov/myncbi/1hy4a586mF0kQ/bibliography/public/
1. Bennett A, Kim H, Thomas D, Biggs P, Ara R, Bosomtwi A, Kang S. Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice. Neuropsychopharmacology. 2026 Mar;51(4):778-790. doi: 10.1038/s41386-025-02264-3. Epub 2025 Oct 13. PMID:41083599
2. Mangieri R, Sirohi S, Fernandez de Velasco EM, Kang S. Editorial: Advances in pharmacotherapy for alcohol use disorder: from mechanisms to clinical interventions. Frontiers in Pharmacology. 2025 Aug 15:16:1671114. PMID: 40894199
3. Basu S, Ro EJ, Liu Z, Kim H, Bennett A, Kang S, Suh H. The Mef2c gene dose-dependently controls hippocampal neurogenesis and the expression of autism-like behaviors. Journal of Neuroscience. 2023 Dec 20:JN-RM-1058-23. doi: 10.1523/JNEUROSCI.1058-23.2023. Epub ahead of print. PMID: 38123360
4. Baker M#, Kang S#, Hong S, Song M, Yang M, Peyton L, Essa H, Lee SW, Choi DS. External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice. (2023) Nature Communications. 14, 4085. #These authors contributed equally to this work. PMID: 37438336
5. Kang S#, Hong SI#, Kang S#, Song M, Yang MA, Essa H, Baker M, Lee J, Bruce RA, Lee SW, Choi DS. Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors. (2023) Science Advances. 9(24), eadh9239. #These authors contributed equally to this work. PMID:37327345
6. Kang S, Choi DS. Astrocyte adenosine signaling and neural mechanisms of goal and habitual reward seeking behaviors. (2021) Neuropsychopharmacology. 46(1):227–228. PMID: 32778692
7. Hong SI, Kang S, Baker M, Choi DS. Astrocyte-neuron interaction in the dorsal striatum-pallidal circuits and alcohol-seeking behaviors. (2021) Neuropharmacology. Oct 15;198:108759. PMID: 34433087
8. Kang S#, Hong SI#, Lee JY, Lee H, Peyton L, Baker M, Choi S, Kim H, Chang SY, Choi DS. Activation of astrocytes in the dorsomedial striatum facilitates transition from habitual to goal-directed reward-seeking behavior. (2020) Biological Psychiatry. November 15; 88:797-808. #equally contributed to this work. PMID: 32564901
9. Khazal FA, Kang S, Holte M, Choi DS, Singh R, Saenz P, Lopez-Barneo J, Maher J. Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency. (2020) FASEB Journal. Nov 27. doi: 10.1096/fj.202002100R. PMID: 33247500
10. Nahar L, Grant CA, Hewett C, Cortes D, Reker AN, Kang S, Choi DS, Nam HW. Regulation of Pv-Specific Interneurons in the Medial Prefrontal Cortex and Reward-Seeking Behaviors. (2020) Journal of Neurochemistry. Jun 27. doi: 10.1111/jnc.15106. PMID: 32594517
11. Baker M, Hong SI, Kang S, Choi DS. Rodent Models for Psychiatric Disorders: Problems and Promises. (2020) Laboratory Animal Research. Apr 15;36:9. PMID: 32322555
12. Hong SI#, Kang S#, Chen J, Choi DS. Indirect medium spiny neurons in the dorsomedial striatum regulate ethanol containing conditioned reward seeking. (2019) Journal of Neuroscience. 39(36) 7206-7217. #equally contributed to this work. PMID: 31315945
13. Kang S, Choi D-S. Possible Benefit and Validity of Supplements for Alcohol Use Disorder. (2019) Alcoholism: Clinical and Experimental Research. May;43(5):780-782. PMID: 30802317
14. Kang S, Li J, Zuo W, Chen P, Gregor D, Fu R, Han X, Bekker A, Ye JH. Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats. (2019) Scientific Reports. 9(1):2714. PMID: 30804373
15. Wininger K, Karpyak V, Kang S, Choi DS. “Central role of amygdala and hypothalamus neural circuits in alcohol withdrawal symptom”. Neuroscience of Alcohol. Elsevier (Editor Victor Preedy). Chapter 26, pp 249-256, 2019. ELSEVIER
16. Starski P, Hong SI, Peyton L, Oliveros A, Wininger K, Hutchison C, Kang S, Karpyak V, Choi DS. Ethanol induces maladaptive impulse control and decreases seeking behaviors in mice. (2019) Addiction Biology. Apr 22:e12754. PMID: 31012186
17. Lindberg D, Andres-Beck L, Jia YF, Kang S, and Choi DS. Purinergic Signaling in Neuron-Astrocyte interactions, Circadian Rhythms and Alcohol Use Disorder. (2018) Frontiers in Physiology. 9:9. PMID: 29467662
18. Kang S, Li J, Bekker A, Ye JH. Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol withdrawn rats. (2018) Neuropharmacology. 129:47-56. PMID: 29128307
19. Li J#, Kang S#, Fu R, Wu L, Wu W, Liu H, Gregor D, Zuo W, Ye JH. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depression-like behaviors and alcohol intake in rats. (2017) Neuropharmacology. 126:108-120. #equally contributed to this work. PMID: 28865912
20. Greene D, Kang S, Hoshi N. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. (2017) Journal of Pharmacology and Experimental Therapeutics. 362:177-185. PMID: 28483800
21. Kang S, Li J, Fu R, Zuo, W, Gregor D, Krnjevic K, Bekker A, Ye JH. Ethanol withdrawal drives anxiety-related behaviors by reducing M-type potassium channel activity in the lateral habenula. (2017) Neuropsychopharmacology. 42(9):1813-1824. PMID: 28387223
22. Shah A, Zuo W, Kang S, Li J, Fu R, Zhang H, Bekker A, Ye JH. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. (2017) Pharmacology Biochemistry and Behavior. 162:94-102. PMID: 28624587
23. Li J, Fu C, Liu H, Fu R, Zuo W, Kang S, Chen P, Gregor D, Paulose R, Bekker A, Ye HJ. Electroacupuncture attenuates hyperalgesia in rats withdrawn from chronic ethanol drinking involving habenular mu opioid receptors. (2017) Alcoholism: Clinical and Experimental Research. 41(3):637-643. PMID: 28166603
24. Zuo W, Wang L, Chen L, Krnjevic K, Fu R, Feng X, He W, Kang S, Shah A, Bekker A, Ye JH. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. (2016) Neuropharmacology. 113:178-187. PMID: 27678415
25. Fu R, Chen X, Zuo W, Li J, Kang S, Zhou LH, Siegel A, Bekker A, Ye JH. Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors. (2016) Neuropharmacology. 107:58-67. PMID: 26921770
26. Kay HY, Greene D, Kang S, Kosenko A, Hoshi N. M-current preservation contributes to anticonvulsant effects of valproic acid. (2015) Journal of Clinical Investigation. 125:3904-3914. PMID: 26348896
27. Kang S. The Role of Casein Kinase 2 in Ion Channel Remodeling After Myocardial Infarction: Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2" by Xinran Li et al. (2015) Cardiovascular Drugs and Therapy. 29(3):207-8. PMID: 26206620
28. Kim H, Kang S, Kim HJ, Choi SH, Shin S, Lee HH, Rhim H, Shin KH. Effect of acute and chronic electroconvulsive shock on 5-hydroxytrypamine 6 receptor immunoreactivity in rat hippocampus. (2014) Experimental Neurobiology. 23(3):231-7. PMID: 25258570
29. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. (2014) Journal of Biological Chemistry. 289(16):11536-44. PMID: 24627475
30. Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. (2012) The EMBO Journal. 31(14):3147-56. PMID: 22643219
31. Greene D, Kang S, Kosenko A, Hoshi N. Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. (2012) Journal of Biological Chemistry. 287(28):23690-7. PMID: 22613709
32. Kang S, Kim HJ, Kim HJ, Shin SK, Choi SH, Lee MS, Shin KH. Effects of reboxetine and citalopram pretreatment on changes in cocaine and amphetamine regulated transcript (CART) expression in rat brain induced by the forced swimming test. (2010) European Journal of Pharmacology. 647(1-3):110-6. PMID: 20826136
33. Moon BH, Kang S, Kim HJ, Shin SK, Choi SH, Lee MS, Kim MK, Shin KH. Effect of reboxetine pretreatment on the FST-induced gene expression profile in the rat lateral septum. (2008) Molecular & Cellular Toxicology. 4(1):31-44. KOREASCIENCE
34. Moon BH, Hong CG, Kim SY, Kim HJ, Shin SK, Kang S, Lee KJ, Kim YK, Lee MS, Shin KH. A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain. (2008) Toxicology and Applied Pharmacology. 233(2):314-22. PMID: 18824019
35. Park SH, Seo YH, Moon BH, Choi SH, Kang S, Lee KJ, Choi SH, Lee MS, Chun BG, Shin KH. Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain. (2008) European Journal of Pharmacology. 589(1-3):58-65. PMID: 18550051
36. Park SH, Choi SH, Lee J, Kang S, Shin YC, Kim HJ, Kim HJ, Shin SK, Lee MS, Shin KH. Effects of repeated citalopram treatments on chronic mild stress-induced growth associated protein-43 mRNA expression in rat hippocampus. (2008) Korean Journal of Physiology and Pharmacology. 12(3):117-23. PMID: 20157404
37. Kim SJ, Park SH, Choi SH, Moon BH, Lee KJ, Kang S, Lee MS, Choi SH, Chun BG, Shin KH. Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats. (2006) Neuropharmacology. 50(7):824-33. PMID: 16504218
1. Bennett A, Kim H, Thomas D, Biggs P, Ara R, Bosomtwi A, Kang S. Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice. Neuropsychopharmacology. 2026 Mar;51(4):778-790. doi: 10.1038/s41386-025-02264-3. Epub 2025 Oct 13. PMID:41083599
2. Mangieri R, Sirohi S, Fernandez de Velasco EM, Kang S. Editorial: Advances in pharmacotherapy for alcohol use disorder: from mechanisms to clinical interventions. Frontiers in Pharmacology. 2025 Aug 15:16:1671114. PMID: 40894199
3. Basu S, Ro EJ, Liu Z, Kim H, Bennett A, Kang S, Suh H. The Mef2c gene dose-dependently controls hippocampal neurogenesis and the expression of autism-like behaviors. Journal of Neuroscience. 2023 Dec 20:JN-RM-1058-23. doi: 10.1523/JNEUROSCI.1058-23.2023. Epub ahead of print. PMID: 38123360
4. Baker M#, Kang S#, Hong S, Song M, Yang M, Peyton L, Essa H, Lee SW, Choi DS. External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice. (2023) Nature Communications. 14, 4085. #These authors contributed equally to this work. PMID: 37438336
5. Kang S#, Hong SI#, Kang S#, Song M, Yang MA, Essa H, Baker M, Lee J, Bruce RA, Lee SW, Choi DS. Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors. (2023) Science Advances. 9(24), eadh9239. #These authors contributed equally to this work. PMID:37327345
6. Kang S, Choi DS. Astrocyte adenosine signaling and neural mechanisms of goal and habitual reward seeking behaviors. (2021) Neuropsychopharmacology. 46(1):227–228. PMID: 32778692
7. Hong SI, Kang S, Baker M, Choi DS. Astrocyte-neuron interaction in the dorsal striatum-pallidal circuits and alcohol-seeking behaviors. (2021) Neuropharmacology. Oct 15;198:108759. PMID: 34433087
8. Kang S#, Hong SI#, Lee JY, Lee H, Peyton L, Baker M, Choi S, Kim H, Chang SY, Choi DS. Activation of astrocytes in the dorsomedial striatum facilitates transition from habitual to goal-directed reward-seeking behavior. (2020) Biological Psychiatry. November 15; 88:797-808. #equally contributed to this work. PMID: 32564901
9. Khazal FA, Kang S, Holte M, Choi DS, Singh R, Saenz P, Lopez-Barneo J, Maher J. Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency. (2020) FASEB Journal. Nov 27. doi: 10.1096/fj.202002100R. PMID: 33247500
10. Nahar L, Grant CA, Hewett C, Cortes D, Reker AN, Kang S, Choi DS, Nam HW. Regulation of Pv-Specific Interneurons in the Medial Prefrontal Cortex and Reward-Seeking Behaviors. (2020) Journal of Neurochemistry. Jun 27. doi: 10.1111/jnc.15106. PMID: 32594517
11. Baker M, Hong SI, Kang S, Choi DS. Rodent Models for Psychiatric Disorders: Problems and Promises. (2020) Laboratory Animal Research. Apr 15;36:9. PMID: 32322555
12. Hong SI#, Kang S#, Chen J, Choi DS. Indirect medium spiny neurons in the dorsomedial striatum regulate ethanol containing conditioned reward seeking. (2019) Journal of Neuroscience. 39(36) 7206-7217. #equally contributed to this work. PMID: 31315945
13. Kang S, Choi D-S. Possible Benefit and Validity of Supplements for Alcohol Use Disorder. (2019) Alcoholism: Clinical and Experimental Research. May;43(5):780-782. PMID: 30802317
14. Kang S, Li J, Zuo W, Chen P, Gregor D, Fu R, Han X, Bekker A, Ye JH. Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats. (2019) Scientific Reports. 9(1):2714. PMID: 30804373
15. Wininger K, Karpyak V, Kang S, Choi DS. “Central role of amygdala and hypothalamus neural circuits in alcohol withdrawal symptom”. Neuroscience of Alcohol. Elsevier (Editor Victor Preedy). Chapter 26, pp 249-256, 2019. ELSEVIER
16. Starski P, Hong SI, Peyton L, Oliveros A, Wininger K, Hutchison C, Kang S, Karpyak V, Choi DS. Ethanol induces maladaptive impulse control and decreases seeking behaviors in mice. (2019) Addiction Biology. Apr 22:e12754. PMID: 31012186
17. Lindberg D, Andres-Beck L, Jia YF, Kang S, and Choi DS. Purinergic Signaling in Neuron-Astrocyte interactions, Circadian Rhythms and Alcohol Use Disorder. (2018) Frontiers in Physiology. 9:9. PMID: 29467662
18. Kang S, Li J, Bekker A, Ye JH. Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol withdrawn rats. (2018) Neuropharmacology. 129:47-56. PMID: 29128307
19. Li J#, Kang S#, Fu R, Wu L, Wu W, Liu H, Gregor D, Zuo W, Ye JH. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depression-like behaviors and alcohol intake in rats. (2017) Neuropharmacology. 126:108-120. #equally contributed to this work. PMID: 28865912
20. Greene D, Kang S, Hoshi N. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. (2017) Journal of Pharmacology and Experimental Therapeutics. 362:177-185. PMID: 28483800
21. Kang S, Li J, Fu R, Zuo, W, Gregor D, Krnjevic K, Bekker A, Ye JH. Ethanol withdrawal drives anxiety-related behaviors by reducing M-type potassium channel activity in the lateral habenula. (2017) Neuropsychopharmacology. 42(9):1813-1824. PMID: 28387223
22. Shah A, Zuo W, Kang S, Li J, Fu R, Zhang H, Bekker A, Ye JH. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. (2017) Pharmacology Biochemistry and Behavior. 162:94-102. PMID: 28624587
23. Li J, Fu C, Liu H, Fu R, Zuo W, Kang S, Chen P, Gregor D, Paulose R, Bekker A, Ye HJ. Electroacupuncture attenuates hyperalgesia in rats withdrawn from chronic ethanol drinking involving habenular mu opioid receptors. (2017) Alcoholism: Clinical and Experimental Research. 41(3):637-643. PMID: 28166603
24. Zuo W, Wang L, Chen L, Krnjevic K, Fu R, Feng X, He W, Kang S, Shah A, Bekker A, Ye JH. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. (2016) Neuropharmacology. 113:178-187. PMID: 27678415
25. Fu R, Chen X, Zuo W, Li J, Kang S, Zhou LH, Siegel A, Bekker A, Ye JH. Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors. (2016) Neuropharmacology. 107:58-67. PMID: 26921770
26. Kay HY, Greene D, Kang S, Kosenko A, Hoshi N. M-current preservation contributes to anticonvulsant effects of valproic acid. (2015) Journal of Clinical Investigation. 125:3904-3914. PMID: 26348896
27. Kang S. The Role of Casein Kinase 2 in Ion Channel Remodeling After Myocardial Infarction: Editorial to: "Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2" by Xinran Li et al. (2015) Cardiovascular Drugs and Therapy. 29(3):207-8. PMID: 26206620
28. Kim H, Kang S, Kim HJ, Choi SH, Shin S, Lee HH, Rhim H, Shin KH. Effect of acute and chronic electroconvulsive shock on 5-hydroxytrypamine 6 receptor immunoreactivity in rat hippocampus. (2014) Experimental Neurobiology. 23(3):231-7. PMID: 25258570
29. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. (2014) Journal of Biological Chemistry. 289(16):11536-44. PMID: 24627475
30. Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. (2012) The EMBO Journal. 31(14):3147-56. PMID: 22643219
31. Greene D, Kang S, Kosenko A, Hoshi N. Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. (2012) Journal of Biological Chemistry. 287(28):23690-7. PMID: 22613709
32. Kang S, Kim HJ, Kim HJ, Shin SK, Choi SH, Lee MS, Shin KH. Effects of reboxetine and citalopram pretreatment on changes in cocaine and amphetamine regulated transcript (CART) expression in rat brain induced by the forced swimming test. (2010) European Journal of Pharmacology. 647(1-3):110-6. PMID: 20826136
33. Moon BH, Kang S, Kim HJ, Shin SK, Choi SH, Lee MS, Kim MK, Shin KH. Effect of reboxetine pretreatment on the FST-induced gene expression profile in the rat lateral septum. (2008) Molecular & Cellular Toxicology. 4(1):31-44. KOREASCIENCE
34. Moon BH, Hong CG, Kim SY, Kim HJ, Shin SK, Kang S, Lee KJ, Kim YK, Lee MS, Shin KH. A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain. (2008) Toxicology and Applied Pharmacology. 233(2):314-22. PMID: 18824019
35. Park SH, Seo YH, Moon BH, Choi SH, Kang S, Lee KJ, Choi SH, Lee MS, Chun BG, Shin KH. Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain. (2008) European Journal of Pharmacology. 589(1-3):58-65. PMID: 18550051
36. Park SH, Choi SH, Lee J, Kang S, Shin YC, Kim HJ, Kim HJ, Shin SK, Lee MS, Shin KH. Effects of repeated citalopram treatments on chronic mild stress-induced growth associated protein-43 mRNA expression in rat hippocampus. (2008) Korean Journal of Physiology and Pharmacology. 12(3):117-23. PMID: 20157404
37. Kim SJ, Park SH, Choi SH, Moon BH, Lee KJ, Kang S, Lee MS, Choi SH, Chun BG, Shin KH. Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats. (2006) Neuropharmacology. 50(7):824-33. PMID: 16504218
Upper figure: Calcium indicating fluorescence in the A2A receptor specifically GCaMP6-expressing striato-pallidal neurons in the Dorsomedial Striatum